Zhang 12_8

نویسندگان

  • XIAOJUN ZHANG
  • HAIMING WEI
  • HUI WANG
  • ZHIGANG TIAN
چکیده

Many chemokine receptors are typically found on natural killer cells, including CX3CR1, the receptor for the chemokine Fractalkine (FKN). This study explored whether interaction between CX3CR1 and FKN is relevant for NK cell functions in cytotoxicity against tumors. FKN expression was examined by polymerase chain reaction and CX3CR1 expression in NK cells was analyzed by flow cytometry. NK cell cytotoxicity was examined by 4-h 51Cr-release assay. FKN was expressed in a variety of tumor cell lines such as K562 cells, an NK-sensitive cell line. Approximately 90% of peripheral blood NK cells and almost all of the NK cell line, NK-92 cells, expressed CX3CR1. Anti-CX3CR1 antibody strongly neutralized the cytotoxicity of NK cells against K562 cells, and pretreatment of NK cells with recombinant soluble FKN improved the cytolytic function on tumor cells. This study demonstrates that an interaction between CX3CR1 on NK cells and FKN on tumor cells is involved in the natural cytotoxicity of NK cells against tumors.

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Kamuhabwa 12_8

In the present study, we evaluated the possibility of enhancing the photodynamic effect of hypericin in transitional cell carcinoma (TCC) spheroids by the use of the oxygen carrier, perfluorodecalin. Following incubation with hypericin, RT-112 TCC spheroids were irradiated in the presence or absence of perfluorodecalin, at light doses of 7 J/cm2 or 28 J/ cm2, delivered at a fluence rate of 15 m...

متن کامل

Hydrogen-rich saline ameliorates hippocampal neuron apoptosis through up-regulating the expression of cystathionine β-synthase (CBS) after cerebral ischemia- reperfusion in rats

Objective(s): This study aimed to evaluate the potential role of hydrogen in rats after cerebral ischemic/reperfusion (I/R) injury. Materials and Methods: The experimental samples were composed of sham group, model group of rats that received middle cerebral artery occlusion (MCAO) for 2 hr followed by reperfusion for 24 hr, and the hydr...

متن کامل

A characterization of a pomonoid $S$ all of its cyclic $S$-posets are regular injective

This work is devoted to give a charcaterization of a pomonoid $S$ such that all cyclic $S$-posets are regular injective.

متن کامل

معرفی تعدادی از کنه‌های پارازیتنگونای خشکی‌زی (Acari: Trombidiformes) انگل بندپایان از برخی مناطق شمال و مرکز ایران

در بررسی و ارزیابی‌های که در سال­های 1389 و 1390 در منطقۀ مهریز و تفت استان یزد و سال­های 1390 و 1391 در مناطق شرقی استان مازندران انجام گرفت، به ترتیب نه و هفت گونه از مرحلۀ لاروی کنه­های پارازیتنگونای خشکی­زی از استان­های یزد و مازندران گرد­آوری شد. گونۀ Atractothrombium sylvaticum (C.L. Koch, 1835) از استان یزد برای نخستین بار از آسیا گزارش می­شود و گونه­های Charletonia terianae Hakimitabar,...

متن کامل

Numerical Modeling of the Shear Module of Alginate Micro-Beads under the Ultrasonic Thermal Effect

The mechanical properties of microscopic particles have been a heated research object for it takes the deformation of micro-beads in the microfluidic environment into account. Sufficient knowledge on mechanical properties of micro-beads would lead to better device design and application for cell mechanics, tissue engineering, etc. The physical properties of alginate beads were examined both in ...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

ثبت نام

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

عنوان ژورنال:

دوره   شماره 

صفحات  -

تاریخ انتشار 2006